Metabolic Activity in Coxiella Burnetii.

Ormsbee, Richard A. (Rocky Mountain Laboratory, Hamilton, Mont.), and Marius G. Peacock. Metabolic activity in Coxiella burnetii. J. Bacteriol. 88:1205-1210. 1964.-Purified suspensions of Coxiella burnetii were shown to utilize alpha-ketoglutarate, succinate, fumarate, malate, oxaloacetate, pyruvate, glutamate, and serine. The addition of nicotinamide adenine dinucleotide(+) was necessary to elicit the maximal rate of oxygen uptake with l-glutamate as substrate, but was unnecessary when other substrates were employed. It was concluded that the Krebs cycle of intermediary carbohydrate metabolism probably operates within C. burnetii, and that pyruvate is the chief energy source.